Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → Piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | N-[3-chloro-phenyl]-4-[2-(1-piperazinyl)-4-pyridyl]-2-pyrimidineamine | HCID 21948237 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Piperazine | HCID 4837 | — |
| 생성물 | N-(3-chlorophenyl)-4-(2-chloropyridin-4-yl)pyrimidin-2-amine | HCID 9905031 | — |
반응 단계
Analogously to Example 1, there is obtained from 100 mg (0.31 mmol) of N-[3-chloro-phenyl]-4-(2-chloro-4-pyridyl)-2-pyrimidineamine and 500 mg (5.63 mmol) of piperazine, from the melt after chromatography (methylene chloride:methanol=95:5), N-[3-chloro-phenyl]-4-[2-(1-piperazinyl)-4-pyridyl]-2-pyrimidineamine;
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05728708 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-8b8f64beacb447798a17fed01f8b02fc |
| 출처 메모 | uspto-grants-1998_03 |