Chlorosulfonic acid → 5-fluoro-4-hydroxy-2-methylbenzenesulfonyl Chloride

HRID 216303노트

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HRID 216303 반응식
[Cl:1][S:2]([OH:5])(=O)=[O:3].[F:6][C:7]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][C:8]=1[OH:14]>ClCCl>[F:6][C:7]1[C:8]([OH:14])=[CH:9][C:10]([CH3:13])=[C:11]([S:2]([Cl:1])(=[O:5])=[O:3])[CH:12]=1

참가 물질

4

반응물 2

HCID 24638Chlorosulfonic acidHCID 182387Phenol, 2-fluoro-5-methyl-

생성물 1

HCID 847898185-fluoro-4-hydroxy-2-methylbenzenesulfonyl Chloride수율 7.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of chlorosulfonic acid (1.5 g, 13.3 mmol) dissolved in 10 mL of dichloromethane was added 2-fluoro-5-methylphenol (1.1 g, 8.86 mmol) dropwise. After 10 minutes, the reaction was quenched by adding to ice water. The reaction was extracted with dichloromethane, washed with brine, dried over MgSO4, filtered, and concentrated to give 150 mg (7.5%) of the title compound.

후처리

  1. customthe reaction was quenched
  2. additionby adding to ice water
  3. extractionThe reaction was extracted with dichloromethane
  4. washwashed with brine
  5. dry with materialdried over MgSO4
  6. filtrationfiltered
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-2f5080c790b047c2ad93840e8b4185fd
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08193227B2

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