Acetonitrile → HCID 68668375, 화합물

HRID 216314

반응식

HRID 216314 반응식
F[B-](F)(F)F.[N:6]#[O+:7].[CH3:8][C:9]([CH3:15])([CH2:13][CH3:14])[CH2:10][CH:11]=[CH2:12].[C:16](#[N:18])[CH3:17]>>[CH3:8][C:9]([CH3:15])([CH2:13][CH3:14])[CH2:10][C:11]1[N:18]=[C:16]([CH3:17])[N:6]([OH:7])[CH:12]=1

참가 물질

4

반응물 3

HCID 6342AcetonitrileHCID 1371364,4-Dimethyl-1-hexeneHCID 11137142Nitrilooxonium tetrafluoroborate

생성물 1

HCID 68668375HCID 68668375, 화합물

실험 절차

Nitrosonium tetrafluoroborate 45 g (0.38 mol) was added in three portions to a 0° C. solution of 4,4-dimethyl-1-hexene (43 g, 0.38 mol) in acetonitrile (100 mL). After stirring at ambient temperature for 1 h, the reaction mixture was filtered and the filtrate was concentrated in vacuo. The residue was dissolved in ethyl acetate and washed with water, saturated aqueous sodium bicarbonate and brine, dried (magnesium sulfate), filtered and concentrated in vacuo to afford 4-(2,2-dimethylbutyl)-2-methyl-1H-imidazol-1-ol which was used in the subsequent step without further purification.

후처리

  1. filtrationthe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated in vacuo
  3. dissolutionThe residue was dissolved in ethyl acetate
  4. washwashed with water, saturated aqueous sodium bicarbonate and brine
  5. dry with materialdried (magnesium sulfate)
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-e8e4cbd842094a0cb5f370941b023fc7
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08193228B2

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