Acetonitrile → 4-(2,2-dimethylpropyl)-2-methyl-1H-imidazol-1-ol

HRID 216317

반응식

[CH3:1][C:2]([CH3:7])([CH3:6])[CH2:3][CH:4]=[CH2:5].F[B-](F)(F)F.[N:13]#[O+:14].[C:15](#[N:17])[CH3:16]>>[CH3:1][C:2]([CH3:7])([CH3:6])[CH2:3][C:4]1[N:17]=[C:15]([CH3:16])[N:13]([OH:14])[CH:5]=1

참가 물질

반응물 3

HCID 6342Acetonitrile

HCID 129844,4-Dimethylpent-1-ene

HCID 11137142Nitrilooxonium tetrafluoroborate

생성물 1

HCID 686676414-(2,2-dimethylpropyl)-2-methyl-1H-imidazol-1-ol

실험 절차

4,4-Dimethyl-1-pentene (59 g, 0.6 mol) was added to a 10° C. suspension of nitrosonium tetrafluoroborate (66 g, 0.56 mmol) in acetonitrile (600 mL) After stirring vigorously at ambient temperature for 30 minutes, acetonitrile was removed in vacuo to afford 4-(2,2-dimethylpropyl)-2-methyl-1H-imidazol-1-ol which was used in the subsequent step without further purification.

후처리

customacetonitrile was removed in vacuo

출처 및 근거

ORD 기록: ord-8f275411a5eb43a3b0991880d70309c4
출처 데이터셋: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08193228B2

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