Acetone → HCID 20382884, 화합물

HRID 2163231노트

반응식

HRID 2163231 반응식
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:17]=[CH:16][C:9]([C:10]([NH:12][CH2:13][CH2:14][OH:15])=[O:11])=[CH:8][CH:7]=1)=[O:4].[S:18]1C=CC=C1CC([O-])=O.[K+].[CH3:28][C:29](C)=[O:30]>>[C:29]([S:18][CH2:2][C:3]([NH:5][C:6]1[CH:17]=[CH:16][C:9]([C:10]([NH:12][CH2:13][CH2:14][OH:15])=[O:11])=[CH:8][CH:7]=1)=[O:4])(=[O:30])[CH3:28]

참가 물질

4

반응물 3

HCID 180AcetoneHCID 203829064-(2-Chloroacetamido)-N-(2-hydroxyethyl)benzamideHCID 23696799Potassium 2-thienylacetate

생성물 1

HCID 20382884HCID 20382884, 화합물수율 57%

실험 절차

Compound 8 -- A mixture of 4-(2-chloroacetamido)-N-(2-hydroxyethyl)benzamide (39.3 g., 0.153 mole) and potassium thiolacetate (18.3 g., 0.16 mole) in 650 ml. of acetone is heated at reflux temperature for a period of 2 hr. After standing overnight, the reaction mixture is filtered, the filtercake washed with acetone, slurried with water, filtered and the filtercake washed with water and dried to afford 34.7 g. of crude product. Crystallization of this material from ethyl acetate-methanol affords analytically pure 4-[2-(ACETYLTHIO)ACETAMIDO]-N-(2-HYDROXYETHYL)BENZAMIDE, m.p. 190.0°-192.0° C. (corr.) in 57% yield.

후처리

  1. temperatureat reflux temperature for a period of 2 hr
  2. filtrationthe reaction mixture is filtered
  3. washthe filtercake washed with acetone
  4. filtrationfiltered
  5. washthe filtercake washed with water
  6. customdried
  7. customto afford 34.7 g
  8. customCrystallization of this material from ethyl acetate-methanol

출처 및 근거

ORD 기록
ord-b6e4216c03f04c48be804aa4c3b9338b
출처 데이터셋
uspto-grants-1979_01
특허 번호
US04132802

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