4-(5-fluoropyridin-2-yl)-N-methoxy-N-methylbenzamide → 1-(4-(5-Fluoropyridin-2-yl)phenyl)ethanone

HRID 216324노트

반응식

HRID 216324 반응식
[CH3:1][Mg]Br.[F:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[CH:22]=[CH:21][C:14]([C:15](N(OC)C)=[O:16])=[CH:13][CH:12]=2)=[N:9][CH:10]=1>O1CCCC1>[F:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[CH:22]=[CH:21][C:14]([C:15](=[O:16])[CH3:1])=[CH:13][CH:12]=2)=[N:9][CH:10]=1

참가 물질

4

반응물 2

HCID 866384894-(5-fluoropyridin-2-yl)-N-methoxy-N-methylbenzamideHCID 178418573HCID 178418573, 화합물

생성물 1

HCID 591619481-(4-(5-Fluoropyridin-2-yl)phenyl)ethanone

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
0 °C

실험 절차

Methylmagnesium bromide (3 M in tetrahydrofuran) (2.1 mL, 6.2 mmol) was added to a −78° C. solution of 4-(5-fluoropyridin-2-yl)-N-methoxy-N-methylbenzamide (800 mg, 3.1 mmol) in tetrahydrofuran (20 mL). After stirring at 0° C. for 30 min, the reaction mixture was quenched with methanol and saturated aqueous ammonium chloride. The organic layer was dried (magnesium sulfate) and concentrated in vacuo. Chromatography over silica eluting with 0-15% ethyl acetate/hexane afforded the title compound.

후처리

  1. customthe reaction mixture was quenched with methanol and saturated aqueous ammonium chloride
  2. dry with materialThe organic layer was dried (magnesium sulfate)
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-fb6eadfff345482abeb6415983a5f2e8
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08193228B2

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