HCID 47149234, 화합물 → 1-(6-(1H-pyrazol-1-yl)pyridin-3-yl)ethanone

HRID 216331노트

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HRID 216331 반응식
[CH3:1][Mg]Br.CON(C)[C:7](=[O:19])[C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH:18]=[CH:17][CH:16]=[N:15]2)=[N:10][CH:9]=1>O1CCCC1>[N:14]1([C:11]2[N:10]=[CH:9][C:8]([C:7](=[O:19])[CH3:1])=[CH:13][CH:12]=2)[CH:18]=[CH:17][CH:16]=[N:15]1

참가 물질

4

반응물 2

HCID 47149234HCID 47149234, 화합물HCID 178418573HCID 178418573, 화합물

생성물 1

HCID 591619701-(6-(1H-pyrazol-1-yl)pyridin-3-yl)ethanone

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Methylmagnesium bromide (3 M in tetrahydrofuran) (3.16 mL, 9.5 mmol) was added to a −78° C. solution of N-methoxy-N-methyl-6-(1H-pyrazol-1-yl)nicotinamide (2.0 g, 8.6 mmol) in tetrahydrofuran (10 mL). After stirring at ambient temperature overnight, the reaction mixture was quenched with brine and extracted with ethyl acetate. The combined organic extracts were dried (magnesium sulfate) and concentrated in vacuo to afford the title compound.

후처리

  1. customthe reaction mixture was quenched with brine
  2. extractionextracted with ethyl acetate
  3. dry with materialThe combined organic extracts were dried (magnesium sulfate)
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-5d0799ced85c4737a9e4e275e5ff81a5
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08193228B2

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