Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → N-[4-(hexadecylamino)benzoyl]-2-methylalanine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Aminoisobutyric acid | HCID 6119 | — |
| 반응물 | 4-Hexadecylaminobenzoyl chloride hydrochloride | HCID 13255322 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | N-[4-(hexadecylamino)benzoyl]-2-methylalanine | HCID 20437359 | — |
반응 단계
A mixture of 5.24 g. of α-aminoisobutyric acid, 50 ml. of pyridine, and 25 ml. of H2O was stirred while 21.1 g. of 4-(hexadecylamino)benzoyl chloride hydrochloride was added. The mixture was stirred for 18 hours at ambient temperature and filtered. The filtrate was evaporated and the residual yellow glass was dissolved in 1N NaOH solution. The solution was extracted with diethyl ether and then acidified with 6N HCl. The precipitate was collected, dried, and recrystallized from acetone, melting point 199°-202° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04136256 |
| 출처 데이터셋 | uspto-grants-1979_01 |
| ORD ID | ord-d18ac09ae513412d9978072dc658ccd1 |
| 출처 메모 | uspto-grants-1979_01 |