Timonacic → 3-[4-(Hexadecylamino)benzoyl]-4-carboxythiazolidine

HRID 2163771

반응식

HRID 2163771 반응식
[CH2:1]([NH:17][C:18]1[CH:35]=[CH:34][C:21]([C:22]([N:24]2[CH:28]([C:29]([O:31]CC)=[O:30])[CH2:27][S:26][CH2:25]2)=[O:23])=[CH:20][CH:19]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].S1CC(C(O)=O)NC1>C(=O)(O)[O-].[Na+].CC(C)=O>[CH2:1]([NH:17][C:18]1[CH:19]=[CH:20][C:21]([C:22]([N:24]2[CH:28]([C:29]([OH:31])=[O:30])[CH2:27][S:26][CH2:25]2)=[O:23])=[CH:34][CH:35]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

참가 물질

4

반응물 2

HCID 9934TimonacicHCID 204373423-[4-(Hexadecylamino)benzoyl]-4-carboethoxythiazolidine

생성물 1

HCID 204373653-[4-(Hexadecylamino)benzoyl]-4-carboxythiazolidine

시약·촉매·용매 1

HCID 86737261Acetone sodium bicarbonate용매

실험 절차

By means of the alkaline hydrolysis method of Example 7, the ethyl ester of Example 21 is converted to the subject carboxylic acid. This acid is also prepared using the procedure of Example 21 except that the acylation of the thiazolidine-4-carboxylic acid is carried out in aqueous acetone sodium bicarbonate solution.

후처리

  1. customBy means of the alkaline hydrolysis method of Example 7
  2. customThis acid is also prepared

출처 및 근거

ORD 기록
ord-5b11191574bb446b90494df4117a7bc3
출처 데이터셋
uspto-grants-1979_01
특허 번호
US04136256

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