Water → N-Methyl-4-nitrobenzenesulfonamide

HRID 216397노트

반응식

HRID 216397 반응식
[CH3:1][NH2:2].[N+:3]([C:6]1[CH:11]=[CH:10][C:9]([S:12](Cl)(=[O:14])=[O:13])=[CH:8][CH:7]=1)([O-:5])=[O:4].O>O1CCCC1>[CH3:1][NH:2][S:12]([C:9]1[CH:10]=[CH:11][C:6]([N+:3]([O-:5])=[O:4])=[CH:7][CH:8]=1)(=[O:14])=[O:13]

참가 물질

5

반응물 3

HCID 962WaterHCID 6329MethylamineHCID 74044-Nitrobenzenesulfonyl chloride

생성물 1

HCID 232993N-Methyl-4-nitrobenzenesulfonamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Methylamine (2 M in tetrahydrofuran) (24 mL, 47.5 mmol) was added to an ambient temperature solution of p-nitrobenzenesulfonyl chloride (3.5 g, 15.8 mmol) in tetrahydrofuran (30 mL). After stirring at ambient temperature for 30 min, the reaction mixture was poured into water and extracted with ethyl aceate. The organic phase was dried (magnesium sulfate) and concentrated to afford N-methyl-4-nitrobenzenesulfonamide which was used without further purification.

후처리

  1. extractionextracted with ethyl aceate
  2. dry with materialThe organic phase was dried (magnesium sulfate)
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-6594074eb51c4fc093bfa9f3e4fc49f6
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08193228B2

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