Aziridine → 4-[3-(1-Aziridinyl)-2-hydroxypropoxy]-9-fluorenone

반응식

[O:1]1[CH2:19][CH:2]1[CH2:3][O:4][C:5]1[C:17]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10](=[O:18])[C:9]=2[CH:8]=[CH:7][CH:6]=1.[CH2:20]1[NH:22][CH2:21]1>>[N:22]1([CH2:19][CH:2]([OH:1])[CH2:3][O:4][C:5]2[C:17]3[C:16]4[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=4)[C:10](=[O:18])[C:9]=3[CH:8]=[CH:7][CH:6]=2)[CH2:20][CH2:21]1

참가 물질

반응물 2

HCID 9033Aziridine

HCID 18678486HCID 18678486, 화합물

생성물 1

HCID 227502124-[3-(1-Aziridinyl)-2-hydroxypropoxy]-9-fluorenone

실험 절차

4 g of 4-(2,3-epoxypropoxy)-9-fluorenone are allowed to stand at room temperature over night together with 15 cc of ethylene imine. The excess ethylene imine is removed by evaporation, the residue is taken up in ether and the solution is concentrated by evaporation until crystallization commences. The title compound has an M.P. of 113°-116°.

후처리

customThe excess ethylene imine is removed by evaporation
concentrationthe solution is concentrated by evaporation until crystallization commences

출처 및 근거

ORD 기록: ord-cf3d26869e524948b945c135cbe522b5
출처 데이터셋: uspto-grants-1979_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04137331

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