참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | N'-tert-butylbenzohydrazide | HCID 299436 | — |
| 반응물 | Isonicotinoyl chloride hydrochloride | HCID 12262826 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | N'-t-butyl-N-benzoyl-N'-isonicotinoylhydrazine | HCID 15767540 | — |
반응 단계
N'-t-butyl-N-benzoylhydrazine (1.0 g, 0.0052 mol) was suspended in 20 ml of toluene. Isonicotinoyl chloride hydrochloride (0.93 g, 0.0052 mol) was added and then a solution of sodium hydroxide (1.25 g of 50% aqueous NaOH) in 5 ml of water was added dropwise. After stirring at 23° C. for 2 hours, the solids were removed by filtration, washed with water and dried in air. The crude product was chromatographed on silica gel using 5% methanol/methylene chloride as eluant to afford pure N'-t-butyl-N-benzoyl-N'-isonicotinoylhydrazine: m.p. >210° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US05424333 |
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| 출처 데이터셋 | uspto-grants-1995_06 |
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| ORD ID | ord-8743c2d7a9fc42ab9163b98b5f3b12a5 |
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| 출처 메모 | uspto-grants-1995_06 |
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