Water → 5-t-Butyl-3-cyclobutanecarbonylaminopyrazole

HRID 2164503노트

반응식

HRID 2164503 반응식
[NH2:1][C:2]1[CH:6]=[C:5]([C:7]([CH3:10])([CH3:9])[CH3:8])[NH:4][N:3]=1.C(N(CC)CC)C.[CH:18]1([C:22](Cl)=[O:23])[CH2:21][CH2:20][CH2:19]1.O>C(Cl)Cl.C(Cl)(Cl)(Cl)Cl>[C:7]([C:5]1[NH:4][N:3]=[C:2]([NH:1][C:22]([CH:18]2[CH2:21][CH2:20][CH2:19]2)=[O:23])[CH:6]=1)([CH3:10])([CH3:9])[CH3:8]

참가 물질

7

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 78705Cyclobutanecarbonyl chlorideHCID 5227873-Amino-5-tert-butylpyrazole

생성물 1

HCID 134770005-t-Butyl-3-cyclobutanecarbonylaminopyrazole

시약·촉매·용매 2

HCID 5943Carbon Tetrachloride용매HCID 6344Dichloromethane용매

실험 절차

4.3 g (0.03 mole) of 3-amino-5-t-butylpyrazole as prepared in Example 1 and 3 g of triethylamine were dissolved in 30 ml of methylene chloride. To this solution was added dropwise 3.6 g of cyclobutanecarboxylic acid chloride dissolved in 30 ml of carbon tetrachloride. The resulting mixture was allowed to stand at room temperature over night. Thereafter, water was added thereto followed by shaking it. Crystals thus formed were collected by filtration and washed with water and carbon tetrachloride to obtain 5-t-butyl-3-cyclobutanecarbonylaminopyrazole.

후처리

  1. waitto stand at room temperature over night
  2. customCrystals thus formed
  3. filtrationwere collected by filtration
  4. washwashed with water and carbon tetrachloride

출처 및 근거

ORD 기록
ord-7b86865510af4e1e9851b0c31e5ea268
출처 데이터셋
uspto-grants-1985_03
특허 번호
US04505739

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