Tert-butyl 2-nitrobenzoate → tert-Butyl 2-aminobenzoate

HRID 2164681노트

반응식

HRID 2164681 반응식
[N+:1]([C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6]([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7])([O-])=O>CO.[C].[Pd]>[NH2:1][C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6]([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7]

참가 물질

4

반응물 1

HCID 4860715Tert-butyl 2-nitrobenzoate

생성물 1

HCID 3430448tert-Butyl 2-aminobenzoate수율 887.3%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

A mixture of tert-butyl 2-nitrobenzoate (2.1 g.) in methanol (200 ml.) was hydrogenated over palladium-carbon (2 g.) with shaking at atmospheric pressure and room temperature for 3.5 hours. The reaction mixture was filtered to remove the catalyst and then evaporated. To the residue were successively added diethyl ether and an aqueous solution of sodium chloride followed by shaking. The organic layer was separated, dried over magnesium sulfate, treated with activated charcoal and then evaporated to give an oil of the title compound (16.13 g.).

후처리

  1. filtrationThe reaction mixture was filtered
  2. customto remove the catalyst
  3. customevaporated
  4. stirringby shaking
  5. customThe organic layer was separated
  6. dry with materialdried over magnesium sulfate
  7. additiontreated with activated charcoal
  8. customevaporated

출처 및 근거

ORD 기록
ord-6574e45b1c90479882da78f4532fb22a
출처 데이터셋
uspto-grants-1985_03
특허 번호
US04506076

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