1-Azido-4-[3-(1-piperidinylmethyl)phenoxy]-2-butanol → 1-Amino-4-{3-[(piperidin-1-yl)methyl]phenoxy}butan-2-ol

HRID 2164742노트

반응식

HRID 2164742 반응식
[N:1]([CH2:4][CH:5]([OH:22])[CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[CH:10]=1)=[N+]=[N-].[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[NH2:1][CH2:4][CH:5]([OH:22])[CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[CH:10]=1

참가 물질

4

반응물 2

HCID 202460071-Azido-4-[3-(1-piperidinylmethyl)phenoxy]-2-butanolHCID 21226445Aluminium lithium hydride

생성물 1

HCID 202460151-Amino-4-{3-[(piperidin-1-yl)methyl]phenoxy}butan-2-ol수율 82%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of 1-azido-4[3-(1-piperidinylmethyl)phenoxy]-2-butanol (10 g) in dry tetrahydrofuran (100 ml) was added dropwise to a stirred suspension of lithium aluminium hydride (4 g) in tetrahydrofuran (200 ml) under nitrogen. The resulting mixture was stirred at room temperature for 1 h and quenched with water (4 ml), followed by 15% sodium hydroxide (4 ml) and water (12 ml). The mixture was then filtered and the residue washed with tetrahydrofuran (50 ml). The combined filtrate was evaporated to give the title compound (7.5 g) as a pale pink oil.

후처리

  1. customquenched with water (4 ml)
  2. filtrationThe mixture was then filtered
  3. washthe residue washed with tetrahydrofuran (50 ml)
  4. customThe combined filtrate was evaporated

출처 및 근거

ORD 기록
ord-c6b2e109218840cebbec43ac0528fdd2
출처 데이터셋
uspto-grants-1985_03
특허 번호
US04507296

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