Potassium Carbonate → HCID 53945181, 화합물

HRID 2164921노트

반응식

HRID 2164921 반응식
[OH:1][C:2]1[C:7]([CH2:8][CH2:9][CH3:10])=[C:6]([OH:11])[CH:5]=[CH:4][C:3]=1[C:12](=[O:14])[CH3:13].[CH3:15][O:16][C:17](=[O:37])[CH2:18][O:19][C:20]1[C:25]([C:26](=[O:28])[CH3:27])=[CH:24][CH:23]=[C:22]([O:29][CH2:30][CH2:31][CH2:32]Br)[C:21]=1[CH2:34][CH2:35][CH3:36].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O.CN(C)C=O>[CH3:15][O:16][C:17](=[O:37])[CH2:18][O:19][C:20]1[C:25]([C:26](=[O:28])[CH3:27])=[CH:24][CH:23]=[C:22]([O:29][CH2:30][CH2:31][CH2:32][O:11][C:6]2[CH:5]=[CH:4][C:3]([C:12](=[O:14])[CH3:13])=[C:2]([OH:1])[C:7]=2[CH2:8][CH2:9][CH3:10])[C:21]=1[CH2:34][CH2:35][CH3:36]

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 27751982',4'-Dihydroxy-3'-propylacetophenoneHCID 53657813HCID 53657813, 화합물

생성물 1

HCID 53945181HCID 53945181, 화합물수율 33%

시약·촉매·용매 2

HCID 180Acetone용매HCID 6228Dimethylformamide용매

실험 절차

A mixture of 1.72 g of 1-(2,4-dihydroxy-3-propylphenyl)ethanone, 3.43 g of [6-acetyl-3-(3-bromopropoxy)-2-propylphenoxy]acetic acid methyl ester, 2.44 g of anhydrous potassium carbonate in 50 ml of anhydrous acetone and 25 ml of anhydrous dimethylformamide was stirred at reflux for 18 hours. The reaction mixture was concentrated in vacuo and the residue was purified by high pressure liquid chromatography to give 1.45 g (33%) of [6-acetyl-3-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]-2-propylphenoxy]acetic acid methyl ester as an oil.

후처리

  1. temperatureat reflux for 18 hours
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. customthe residue was purified by high pressure liquid chromatography

출처 및 근거

ORD 기록
ord-fefa3762792f418698fd34271cc1f421
출처 데이터셋
uspto-grants-1985_03
특허 번호
US04507498

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