Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → Methyl 6-(4-acetyl-3-hydroxy-2-propylphenoxy)hexanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2',4'-Dihydroxy-3'-propylacetophenone | HCID 2775198 | — |
| 반응물 | Methyl 6-Bromohexanoate | HCID 4170292 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Methyl 6-(4-acetyl-3-hydroxy-2-propylphenoxy)hexanoate | HCID 14330007 | 90.4% |
반응 단계
A mixture of 5.0 g of 1-(2,4-dihydroxy-3-propylphenyl)ethanone, 5.4 g of methyl 6-bromohexanoate and 5.4 g of anhydrous potassium carbonate in 50 ml of anhydrous dimethylformamide was stirred and heated at 75° for 10 hours. The solvent was removed in vacuo and the residue was purified by column chromatography on 125 g of silica gel. Elution with 25% ethyl acetate-hexane gave 7.5 g (90% yield) of 6-(4-acetyl-3-hydroxy-2-propylphenoxy)hexanoic acid methyl ester as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04507498 |
| 출처 데이터셋 | uspto-grants-1985_03 |
| ORD ID | ord-d54fa40d16e14f92bfc56367454ce3be |
| 출처 메모 | uspto-grants-1985_03 |