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Acetone → HCID 70486976, 화합물

HRID 2164958
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HRID 2164958 반응식
C(OC(=O)[CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15](=[O:17])[CH3:16])=[C:11]([O:18][CH2:19][CH2:20][CH2:21][O:22][CH2:23][CH2:24][CH2:25]Br)[C:10]=1[CH2:27][CH2:28][CH3:29])C.[OH:31][C:32]1[C:37]([CH2:38][CH2:39][CH3:40])=[C:36]([OH:41])[CH:35]=[CH:34][C:33]=1[C:42](=[O:44])[CH3:43].[C:45](=[O:48])([O-])[O-:46].[K+].[K+].[CH3:51][C:52](C)=O>CN(C)C=O>[CH2:51]([O:46][C:45](=[O:48])[CH:7]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15](=[O:17])[CH3:16])=[C:11]([O:18][CH2:19][CH2:20][CH2:21][O:22][CH2:23][CH2:24][CH2:25][O:41][C:36]2[CH:35]=[CH:34][C:33]([C:42](=[O:44])[CH3:43])=[C:32]([OH:31])[C:37]=2[CH2:38][CH2:39][CH3:40])[C:10]=1[CH2:27][CH2:28][CH3:29])[CH2:6][CH3:5])[CH3:52]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 180AcetoneHCID 11430Potassium CarbonateHCID 27751982',4'-Dihydroxy-3'-propylacetophenoneHCID 14330015HCID 14330015, 화합물

생성물 1

HCID 70486976HCID 70486976, 화합물수율 82%

시약·촉매·용매 1

HCID 6228Dimethylformamide
용매

실험 절차

A mixture of 2.13 g (0.0044 mole) of 4-[4-acetyl-3-[3-(3-bromopropoxy)propoxy]-2-propylphenoxy]butanoic acid ethyl ester, 0.85 g (0.0044 mole) of 1-(2,4-dihydroxy-3-propylphenyl)ethanone and 1.2 g (0.0087 mole) of potassium carbonate in 40 ml of anhydrous acetone and 20 ml of anhydrous dimethylformamide was stirred at reflux for 20 hours. The solvents were removed in vacuo and the residue was purified by HPLC using 35% ethyl acetate-hexane to give 2.15 g (82% yield) of [4-acetyl-3-[3-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]propoxy]-2-propylphenoxy]butanoic acid ethyl ester as an oil.

후처리

  1. temperatureat reflux for 20 hours
  2. customThe solvents were removed in vacuo
  3. customthe residue was purified by HPLC

출처 및 근거

ORD 기록
ord-ef4c11d2875a4f5a86b45cf5f0044138
출처 데이터셋
uspto-grants-1985_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04507498

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