3-Ethoxy-2-methyl-2-propenal → (5-Methylpyrimidin-2-yl)methanol

반응식

C(O[CH:4]=[C:5]([CH3:8])[CH:6]=O)C.Cl.[OH:10][CH2:11][C:12]([NH2:14])=[NH:13]>>[OH:10][CH2:11][C:12]1[N:14]=[CH:4][C:5]([CH3:8])=[CH:6][N:13]=1

참가 물질

반응물 2

HCID 5591983-Ethoxy-2-methyl-2-propenal

HCID 122173662-Hydroxy-acetamidine hydrochloride

생성물 1

HCID 23043337(5-Methylpyrimidin-2-yl)methanol

실험 절차

2-Hydroxymethyl-5-methylpyrimidine was prepared by the reaction of 3-ethoxy-2-methyl acrolein and hydroxyacetamidine hydrochloride following a similar procedure to that described by Kim and McKee (J. Org. Chem., 35, 455 (1970)). Proton magnetic resonance spectrum (CDCl3 ; δ in ppm): 2.32 (3H,s); 3.6 (1H,bs); 4.80 (2H,s); 8.54 (2H,s).

출처 및 근거

ORD 기록: ord-f1267336107b431d914a2bb7a88c6b97
출처 데이터셋: uspto-grants-1990_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04938793

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