Pyridine → 4-[[8-[(4-Methylphenyl)sulfonyl]octyl]oxy]-1,1-biphenyl

HRID 2165061노트

반응식

HRID 2165061 반응식
[C:1]1([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:6]=[CH:5][C:4]([O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]O)=[CH:3][CH:2]=1.[S:23](Cl)([C:26]1[CH:32]=[CH:31][C:29]([CH3:30])=[CH:28][CH:27]=1)(=[O:25])=[O:24].N1C=CC=CC=1>O>[CH3:30][C:29]1[CH:31]=[CH:32][C:26]([S:23]([CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][O:7][C:4]2[CH:5]=[CH:6][C:1]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:2][CH:3]=2)(=[O:25])=[O:24])=[CH:27][CH:28]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 73974-Toluenesulfonyl chlorideHCID 139591154-(8-Hydroxyoctyl)oxybiphenyl

생성물 1

HCID 230435324-[[8-[(4-Methylphenyl)sulfonyl]octyl]oxy]-1,1-biphenyl

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 33.26 g of 8-([1,1'-biphenyl]-4-yloxy)-1-octanol, 23.37 g of tosyl chloride and 200 ml of pyridine was allowed to stand in a refrigerator overnight. Then water was added, the solid collected, washed with water and dissolved in chloroform. This solution was washed with dilute hydrochloric acid then saturated aqueous sodium bicarbonate, dried and the solvent removed, giving the desired compound as a white solid.

후처리

  1. customto stand in a refrigerator overnight
  2. customthe solid collected
  3. washwashed with water
  4. dissolutiondissolved in chloroform
  5. washThis solution was washed with dilute hydrochloric acid
  6. dry with materialsaturated aqueous sodium bicarbonate, dried
  7. customthe solvent removed

출처 및 근거

ORD 기록
ord-70e98206962349cebf1c09a0baac64ff
출처 데이터셋
uspto-grants-1990_07
특허 번호
US04939127

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