Thionyl Chloride → 2-(1-Chloroethyl)-1,3-benzothiazole

HRID 2165073노트

반응식

HRID 2165073 반응식
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH:10](O)[CH3:11].S(Cl)([Cl:15])=O>C(Cl)Cl>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH:10]([Cl:15])[CH3:11]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 28306741-(1,3-Benzothiazol-2-yl)ethan-1-ol

생성물 1

HCID 109979582-(1-Chloroethyl)-1,3-benzothiazole

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 1-(2-benzothiazolyl)ethanol (2.5 g) prepared according to J. Indian Chem. Soc., 566 (1974) in methylene chloride (50 ml) was added thionyl chloride (3.32 g) and the resulting solution stirred at room temperature for 1 hour. The solution was poured onto ice-water (100 ml) and the organic extract separated. This extract was washed with aqueous bicarbonate (10 ml of a 5% solution) and then with water (50 ml). The methylene chloride layer was dried over anhydrous magnesium sulfate and evaporated to a light yellow oil (2.08 g).

후처리

  1. additionThe solution was poured onto ice-water (100 ml)
  2. extractionthe organic extract
  3. customseparated
  4. washThis extract was washed with aqueous bicarbonate (10 ml of a 5% solution) and then with water (50 ml)
  5. dry with materialThe methylene chloride layer was dried over anhydrous magnesium sulfate
  6. customevaporated to a light yellow oil (2.08 g)

출처 및 근거

ORD 기록
ord-b7ea343a2c8946b4a3ba7c2e6a332844
출처 데이터셋
uspto-grants-1990_07
특허 번호
US04939140

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