Carbon Dioxide → 2,6-Dichloro-3,5-difluorophenol
반응식
[Cl:1][C:2]1[C:3]([F:14])=[C:4]([C:8]([F:13])=[C:9]([Cl:12])[C:10]=1[OH:11])C(O)=O.CN(C)C=O.C(=O)=O.C1(C)C=CC=CC=1>O>[Cl:1][C:2]1[C:3]([F:14])=[CH:4][C:8]([F:13])=[C:9]([Cl:12])[C:10]=1[OH:11]참가 물질
6
실험 절차
50 g of 3,5-dichloro-2,6-difluoro-4-hydroxy-benzoic acid and 10 ml of dimethylformamide are mixed and heated. At 105°-130° C., carbon dioxide evolves, and the reaction is allowed to run to completion at this temperature. 200 ml of toluene and then 80 ml of water are subsequently stirred into the mixture, the phases are separated, and the organic phase is dried and subsequently distilled. 34 g product of boiling point 87°-8° C. are obtained; nD20 : 1.5310.
후처리
- temperatureheated
- customAt 105°-130° C.
- customthe phases are separated
- customthe organic phase is dried
- distillationsubsequently distilled
출처 및 근거
- ORD 기록
- ord-0cd1443ef24e4c61b268de8bf0872d8d
- 출처 데이터셋
- uspto-grants-1990_07
- 특허 번호
- US04939170
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