Methanol → HCID 14326126, 화합물

HRID 2165218노트

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HRID 2165218 반응식
[C-:1]#[N:2].[Na+].[CH3:4][C:5]1[C:12]([F:13])=[C:11]([F:14])[C:8]([CH:9]=[O:10])=[C:7]([F:15])[C:6]=1[F:16].CO>O>[C:1]([CH:9]([OH:10])[C:8]1[C:7]([F:15])=[C:6]([F:16])[C:5]([CH3:4])=[C:12]([F:13])[C:11]=1[F:14])#[N:2]

참가 물질

5

반응물 3

HCID 887MethanolHCID 8929Sodium CyanideHCID 132680124-Methyl-2,3,5,6-tetrafluoro-benzaldehyde2회

생성물 1

HCID 14326126HCID 14326126, 화합물수율 99.5%

시약·촉매·용매 1

HCID 962Water용매2회

반응 조건

온도
0 °C

실험 절차

1.66 g of sodium cyanide were introduced into a mixture of 4 g of 4-methyl-2,3,5,6-tetrafluorobenzaldehyde, 4 g of 4-methyl-2,3,5,6-tetrafluorobenzaldehyde, 70 ml of methyl alcohol and 20 ml of water and the mixture was cooled to 0° C. The reaction mixture was stirred for 1 hour at 0° C. and was poured into water. Extraction was carried out with ether and the ethereal phases were dried and evaporated to dryness under reduced pressure to obtain 4.54 g of the product melting at 124° C.

후처리

  1. extractionExtraction
  2. customthe ethereal phases were dried
  3. customevaporated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-14b1c62fa2994ceba94f146d05fa247f
출처 데이터셋
uspto-grants-1990_07
특허 번호
US04939172

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