Benzyl O-(O-benzyl-N-benzyloxycarbonyl-L-serinyl)-N-trifluoroacetyl-L-serinate → O-(L-serinyl)-N-trifluoroacetyl-L-serine

HRID 2165227노트

반응식

HRID 2165227 반응식
C([O:8][CH2:9][C@@H:10]([C:22]([O:24][CH2:25][C@@H:26]([C:34]([O:36]CC1C=CC=CC=1)=[O:35])[NH:27][C:28](=[O:33])[C:29]([F:32])([F:31])[F:30])=[O:23])[NH:11]C(OCC1C=CC=CC=1)=O)C1C=CC=CC=1>[Pd].C(O)(=O)C>[NH2:11][C@H:10]([C:22]([O:24][CH2:25][C@@H:26]([C:34]([OH:36])=[O:35])[NH:27][C:28](=[O:33])[C:29]([F:32])([F:31])[F:30])=[O:23])[CH2:9][OH:8]

참가 물질

4

반응물 1

HCID 18639970Benzyl O-(O-benzyl-N-benzyloxycarbonyl-L-serinyl)-N-trifluoroacetyl-L-serinate

생성물 1

HCID 18640004O-(L-serinyl)-N-trifluoroacetyl-L-serine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 176Acetic Acid용매

실험 절차

A mixture of benzyl O-(O-benzyl-N-benzyloxycarbonyl-L-serinyl)-N-trifluoroacetyl-L-serinate (1 g) and 10% palladium on activated carbon (1 g) in acetic acid (30 ml) was hydrogenated under hydrogen at 40 psi at room temperature for 6 hours. The reaction mixture was filtered with Celite (filter aid, trade mark, made by Nakarai Chemicals) and the filtrate was concentrated in vacuo and the residue was diluted with water (50 ml) and lyophylized to give O-(L-serinyl)-N-trifluoroacetyl-L-serine (430 ml).

후처리

  1. filtrationThe reaction mixture was filtered with Celite (filter aid, trade mark, made by Nakarai Chemicals)
  2. concentrationthe filtrate was concentrated in vacuo
  3. additionthe residue was diluted with water (50 ml)

출처 및 근거

ORD 기록
ord-d644a460fa7b466aabd2d7754067c494
출처 데이터셋
uspto-grants-1990_07
특허 번호
US04939241

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