benzyl O-acetoacetyl-N-trifluoroacetyl-L-serinate → O-acetoacetyl-N-trifloroacetyl-L-serine

HRID 2165229노트

반응식

HRID 2165229 반응식
[C:1]([O:7][CH2:8][C@@H:9]([C:17]([O:19]CC1C=CC=CC=1)=[O:18])[NH:10][C:11](=[O:16])[C:12]([F:15])([F:14])[F:13])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4]>[Pd].C(O)C>[C:1]([O:7][CH2:8][C@@H:9]([C:17]([OH:19])=[O:18])[NH:10][C:11](=[O:16])[C:12]([F:15])([F:14])[F:13])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4]

참가 물질

4

반응물 1

HCID 53948101benzyl O-acetoacetyl-N-trifluoroacetyl-L-serinate

생성물 1

HCID 18640001O-acetoacetyl-N-trifloroacetyl-L-serine수율 95.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of benzyl O-acetoacetyl-N-trifluoroacetyl-L-serinate (320 mg) and 10% palladium on activated carbon (40 mg) in ethanol (10 ml) was hydrogenated under hydrogen at one atom for 20 minutes. The mixture was filtered with Celite (filter aid, trade mark, made by Nakarai Chemicals) and the filtrate was concentrated to give O-acetoacetyl-N-trifloroacetyl-L-serine (232 mg).

후처리

  1. filtrationThe mixture was filtered with Celite (filter aid, trade mark, made by Nakarai Chemicals)
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-4c02b58b79d64e88a2ff0a6eecbabd51
출처 데이터셋
uspto-grants-1990_07
특허 번호
US04939241

반응 노트

불러오는 중…