Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Allyl chloroacetate → (3S-trans)-[[3-[(t-Butyloxycarbonyl)amino]-2-methyl-4-oxo-1-azetidinyl]oxy]acetic acid, 2-propenyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Allyl chloroacetate | HCID 76206 | — |
| 반응물 | tert-butyl N-[(2S,3S)-1-hydroxy-2-methyl-4-oxoazetidin-3-yl]carbamate | HCID 12946603 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | (3S-trans)-[[3-[(t-Butyloxycarbonyl)amino]-2-methyl-4-oxo-1-azetidinyl]oxy]acetic acid, 2-propenyl ester | HCID 57212832 | — |
반응 단계
To a solution of 17.3 g of (3S-trans)-3-(t-butyloxycarbonylamino)-1-hydroxy-4-methyl-2-azetidinone and 12.9 g of chloroacetic acid, 2-propenyl ester in 350 ml of dry dimethylformamide. The mixture was allowed to stand for 4 days at room temperature and subsequently worked up as described in Example 90B. Yield 25.5 g of crude ester.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04939253 |
| 출처 데이터셋 | uspto-grants-1990_07 |
| ORD ID | ord-38732c53d02e4c1f88f3a8f3f7fb6405 |
| 출처 메모 | uspto-grants-1990_07 |