Thionyl Chloride → HCID 20063999, 화합물

HRID 2165392노트

반응식

HRID 2165392 반응식
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:20]=[CH:19][C:12]([C:13]([NH:15][CH2:16][CH2:17][OH:18])=O)=[CH:11][CH:10]=1.S(Cl)(Cl)=O>CCOCC>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:20]=[CH:19][C:12]([C:13]2[O:18][CH2:17][CH2:16][N:15]=2)=[CH:11][CH:10]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 200640874-(6-bromohexyloxy)-N-(2-hydroxyethyl)benzamide

생성물 1

HCID 20063999HCID 20063999, 화합물수율 95%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To 100 g of 4-(6-bromohexyloxy)-N-(2-hydroxyethyl)benzamide was added dropwise 112 g (75 ml) of thionyl chloride over a 20 minute period. The mixture was stirred for 45 minutes and then diluted with several volumes of ether. A solid product separated which was collected and rinsed with ether to give 90 g of 2-[4-(6-bromohexyloxy)phenyl]-4,5-dihydro-oxazole.

후처리

  1. customA solid product separated which
  2. customwas collected
  3. washrinsed with ether

출처 및 근거

ORD 기록
ord-d0c07c5dc48748c98ed81208cd5d47b5
출처 데이터셋
uspto-grants-1990_07
특허 번호
US04939267

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