Quinone → HCID 20089837, 화합물
반응식
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[CH:5][C:6](=[O:9])O[CH:8]=1.C1(=O)[CH:17]=[CH:16][C:15](=[O:18])[CH:14]=[CH:13]1>ClC1C=CC=CC=1Cl>[F:10][C:2]([F:1])([F:11])[C:3]1[CH:4]=[C:5]2[C:14](=[CH:13][CH:8]=1)[C:15](=[O:18])[CH:16]=[CH:17][C:6]2=[O:9]참가 물질
4
실험 절차
A mixture of 1.64 g (0.01 mmol) of 5-trifluoromethyl-2-oxo-2H-pyrane and 5.4 g (0.05 mol) of 1,4-benzoquinone in 7 ml of 1,2-dichlorobenzene is heated for 12 hours to 180° C. The reaction mixture is then concentrated by evaporation at 90°/20 mbar, and the distillation residue is chromatographed over 150 g of silica gel 60 (eluant: 19:1 mixture of CH2Cl2 /acetone; 0.3 bar overpressure). Yield: 1.82 g (80.52%); m.p. 80°-85° C.
후처리
- temperatureis heated for 12 hours to 180° C
- concentrationThe reaction mixture is then concentrated by evaporation at 90°/20 mbar
- distillationthe distillation residue is chromatographed over 150 g of silica gel 60 (eluant: 19:1 mixture of CH2Cl2 /acetone; 0.3 bar overpressure)
출처 및 근거
- ORD 기록
- ord-03fefac708754589a854650a52794283
- 출처 데이터셋
- uspto-grants-1990_07
- 특허 번호
- US04940516
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