Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
7-Chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid → 6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(3-(methoxymethyl)-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 7-Chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid | HCID 57338 | — |
| 반응물 | 2-(Methoxymethyl)piperazine | HCID 14230264 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(3-(methoxymethyl)-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid | HCID 14839406 | — |
반응 단계
A 906 mg portion of 7-chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and 1.4 g of 2-(methoxymethyl)piperazine were added to 10 ml of pyridine and reacted as described in Example 81, giving 187 mg of the desired product, mp 216°-218° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04940710 |
| 출처 데이터셋 | uspto-grants-1990_07 |
| ORD ID | ord-8125365767bf4ef0b61cfafca36f90ea |
| 출처 메모 | uspto-grants-1990_07 |