2-(1,1-Difluoroethyl)pyrazine → 2-(1,1-Difluoroethyl)piperazine

HRID 2165692노트

반응식

HRID 2165692 반응식
[F:1][C:2]([C:5]1[CH:6]=[N:7][CH:8]=[CH:9][N:10]=1)([F:4])[CH3:3].[H][H]>CO.[Pt]=O>[F:1][C:2]([CH:5]1[NH:10][CH2:9][CH2:8][NH:7][CH2:6]1)([F:4])[CH3:3]

참가 물질

5

반응물 2

HCID 197635642-(1,1-Difluoroethyl)pyrazineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 197635812-(1,1-Difluoroethyl)piperazine

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 887Methanol용매

실험 절차

A 4.3 g portion of 3-(1,1-difluoroethyl)pyrazine in 25 ml of methanol was reduced with 50 psi hydrogen and 750 mg of platinum oxide at 20° C. for 5 hours. The resulting oil was purified by chromatography, giving about 700 mg of 3-(1,1-difluoroethyl)piperazine.

후처리

  1. customThe resulting oil was purified by chromatography

출처 및 근거

ORD 기록
ord-7053e119313444eda8d7a9bd2c4a6746
출처 데이터셋
uspto-grants-1990_07
특허 번호
US04940710

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