Sulfuryl chloride → 2-Chloro-1-(3,5-di-tert-butyl-4-hydroxyphenyl)ethan-1-one

HRID 2165736노트

반응식

HRID 2165736 반응식
S(Cl)([Cl:4])(=O)=O.[C:6]([C:10]1[CH:11]=[C:12]([C:21](=[O:23])[CH3:22])[CH:13]=[C:14]([C:17]([CH3:20])([CH3:19])[CH3:18])[C:15]=1[OH:16])([CH3:9])([CH3:8])[CH3:7]>C(Cl)Cl>[Cl:4][CH2:22][C:21]([C:12]1[CH:11]=[C:10]([C:6]([CH3:9])([CH3:7])[CH3:8])[C:15]([OH:16])=[C:14]([C:17]([CH3:20])([CH3:19])[CH3:18])[CH:13]=1)=[O:23]

참가 물질

4

반응물 2

HCID 24648Sulfuryl chlorideHCID 6162963',5'-Bis(tert-butyl)-4'-hydroxyacetophenone

생성물 1

HCID 142109772-Chloro-1-(3,5-di-tert-butyl-4-hydroxyphenyl)ethan-1-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

16.2 g (0.12 mol) of sulfuryl chloride in 50 ml of methylene chloride were added dropwise while stirring to a solution of 19.9 g (0.08 mol) of 1-(3,5-di-tert.butyl-4-hydroxyphenyl)-ethanone in 250 ml of methylene chloride at room temperature. After stirring for 3 hours at room temperature, the batch was washed by shaking first with water and then with a saturated sodium hydrogen carbonate solution, and the methylene chloride phase was dried over sodium sulfate and evaporated under reduced pressure.

후처리

  1. washthe batch was washed
  2. stirringby shaking first with water
  3. dry with materialwith a saturated sodium hydrogen carbonate solution, and the methylene chloride phase was dried over sodium sulfate
  4. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-76ee66c018ac4272baa47d8ba1f61b90
출처 데이터셋
uspto-grants-1990_07
특허 번호
US04940790

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