Thionyl Chloride → 3,4,5-Trihydroxybenzonitrile

HRID 2165969

반응식

HRID 2165969 반응식
[C:1]([NH2:12])(=O)[C:2]1[CH:10]=[C:8]([OH:9])[C:6]([OH:7])=[C:4]([OH:5])[CH:3]=1.S(Cl)(Cl)=O>C(OCC)(=O)C>[C:1](#[N:12])[C:2]1[CH:3]=[C:4]([OH:5])[C:6]([OH:7])=[C:8]([OH:9])[CH:10]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 692563,4,5-Trihydroxybenzamide

생성물 1

HCID 137468353,4,5-Trihydroxybenzonitrile수율 86%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

반응 조건

온도
90 °C

실험 절차

A reaction mixture containing 23.5 g. of gallamide, 180 ml. of ethyl acetate and 35 ml. of thionylchloride was refluxed for about 18 hours. The volatile contents were removed by evaporation in vacuo and the resulting residue dissolved in 215 ml. of water. This aqueous solution was heated to about 90° C. until the evolution of gas had ceased. The aqueous solution was filtered through charcoal and the water removed from the filtrate by evaporation. 18 g. of gallonitrile were obtained melting at about 219° C. with decomposition (86% yield). Other nitriles useful as starting materials can be prepared similarly.

후처리

  1. additionA reaction mixture containing 23.5 g
  2. customThe volatile contents were removed by evaporation in vacuo
  3. dissolutionthe resulting residue dissolved in 215 ml
  4. filtrationThe aqueous solution was filtered through charcoal
  5. customthe water removed from the filtrate by evaporation

출처 및 근거

ORD 기록
ord-5b5f25eafe7642dd8bc0aa312c13b930
출처 데이터셋
uspto-grants-1990_07
특허 번호
US04942253

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