Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(Thiophen-3-ylmethyl)piperazine → 1-[4-(2,3-Dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yloxy)-1-oxobutyl]-4-(3-thienylmethyl)piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(Thiophen-3-ylmethyl)piperazine | HCID 3494696 | — |
| 반응물 | 4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyric acid | HCID 14280990 | — |
| 생성물 | 1-[4-(2,3-Dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yloxy)-1-oxobutyl]-4-(3-thienylmethyl)piperazine | HCID 15005631 | — |
반응 단계
Reaction of N-(3-thienylmethyl)piperazine and 4-[(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]butyric acid (2g) analogously to the procedure of Example 4 gave the title compound after crystallization from methanol/diethyl ether as the dihydrochloride salt; yield 3.35 g (91%), m.p. indistinct, decomposed at 245°-250° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04943573 |
| 출처 데이터셋 | uspto-grants-1990_07 |
| ORD ID | ord-496c6f4b0ad64cec8467b70e6ae8c920 |
| 출처 메모 | uspto-grants-1990_07 |