Veratryl chloride → HCID 14499767, 화합물

HRID 2166376노트

반응식

HRID 2166376 반응식
[N:1]1[CH:6]=[CH:5][C:4]([C:7]([N:9]2[CH2:18][CH2:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH2:10]2)=[O:8])=[CH:3][CH:2]=1.[CH3:19][O:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][C:28]=1[O:29][CH3:30])[CH2:24][Cl:25]>C(OCC)(=O)C>[Cl-:25].[CH3:19][O:20][C:21]1[CH:22]=[C:23]([CH2:24][N+:1]2[CH:2]=[CH:3][C:4]([C:7]([N:9]3[CH2:18][CH2:17][C:16]4[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=4)[CH2:10]3)=[O:8])=[CH:5][CH:6]=2)[CH:26]=[CH:27][C:28]=1[O:29][CH3:30]

참가 물질

4

반응물 2

HCID 81740Veratryl chlorideHCID 4137929HCID 4137929, 화합물

생성물 1

HCID 14499767HCID 14499767, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 4.76 g (20 mmol) of 2-[(4-pyridyl)carbonyl]-1,2,3,4-tetrahydroisoquinoline, 4.5 g (24 mmol) of 3,4-dimethoxybenzyl chloride and 200 ml of ethyl acetate is heated under reflux for 20 h. The mixture obtained is allowed to cool, and the precipitate is separated off by filtration and washed with ether. 6.6 g of salt are collected, this being used without further purification in the following stage.

후처리

  1. temperatureis heated
  2. temperatureunder reflux for 20 h
  3. customThe mixture obtained
  4. temperatureto cool
  5. customthe precipitate is separated off by filtration
  6. washwashed with ether
  7. custom6.6 g of salt are collected
  8. customthis being used without further purification in the following stage

출처 및 근거

ORD 기록
ord-7acb3d3a9b834bdb9ed5864ba5631ab7
출처 데이터셋
uspto-grants-1990_07
특허 번호
US04945096

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