Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenylglyoxylic Acid → N'-t-butyl-N'-benzoylcarbonyl-N-benzoylhydrazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenylglyoxylic Acid | HCID 11915 | — |
| 반응물 | Methanesulfonyl chloride | HCID 31297 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | N-(tert-butyl)benzohydrazide | HCID 1275961 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | N'-t-butyl-N'-benzoylcarbonyl-N-benzoylhydrazine | HCID 19368006 | 70% |
반응 단계
N'-t-butyl-N'-benzoylhydrazine (1 g), benzoyl formic acid (0.7 g) and methanesulfonyl chloride (0.7 g) were stirred in toluene (30 ml) and saturated sodium bicarbonate (10 ml) at approximately 5° C. Triethylamine was added slowly, dropwise to the reaction mixture and stirred 1 hour at room temperature. After stirring for 1 hour, the reaction mixture was diluted with toluene (25 ml) and washed with water several times. The organic layers were dried over magnesium sulfate, filtered and the toluene rotavapped off to afford a white solid. After column chromatography, the product was obtained as a white solid in approximately 70% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05424333 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-8c3ff157d51443f48a219a96f1d4bdcc |
| 출처 메모 | uspto-grants-1995_06 |