Imidazole → 1H-Imidazol-2-amine, 4,5-dihydro-N-(2,6-dichlorophenyl)-1-(3-pyridinylcarbonyl)-

HRID 2166827노트

반응식

HRID 2166827 반응식
N1C=CN=C1.[C:6](Cl)(=[O:13])[C:7]1[CH:12]=[CH:11][CH:10]=[N:9][CH:8]=1.[Cl:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[C:17]=1[NH:23][C:24]1[NH:25][CH2:26][CH2:27][N:28]=1>O1CCCC1>[C:6]([N:28]1[CH2:27][CH2:26][N:25]=[C:24]1[NH:23][C:17]1[C:18]([Cl:22])=[CH:19][CH:20]=[CH:21][C:16]=1[Cl:15])(=[O:13])[C:7]1[CH:12]=[CH:11][CH:10]=[N:9][CH:8]=1

참가 물질

5

반응물 3

HCID 795ImidazoleHCID 2803ClonidineHCID 82604Nicotinoyl chloride

생성물 1

HCID 30619571H-Imidazol-2-amine, 4,5-dihydro-N-(2,6-dichlorophenyl)-1-(3-pyridinylcarbonyl)-수율 71.6%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매3회

실험 절차

3.40 g (50 millimoles) of imidazole are dissolved in 25 ml of absolute tetrahydrofuran, a solution of 3.54 g (25 millimoles) of nicotinoyl chloride in 25 ml of absolute tetrahydrofuran is added dropwise at room temperature, and the mixture is stirred for a further 2 hours. The imidazole hydrochloride which has precipitated is then filtered off, the filter residue is washed with a small amount of anhydrous tetrahydrofuran, the combined filtrates are added to a solution of 4.6 g (20 millimoles) of 2-(2',6'-dichlorophenylamino)-2-imidazoline in 25 ml of absolute tetrahydrofuran, and the mixture is stirred overnight. The solvent is then stripped off under reduced pressure on a rotary evaporator and the residue is twice recrystallized from isopropanol. 4.8 g of pure 1-nicotinoyl-2-(2',6'-dichlorophenylamino)-2-imidazoline of melting point 172.5°-174° C. are obtained; the material is identical with the product described in Example 1.

후처리

  1. customThe imidazole hydrochloride which has precipitated
  2. filtrationis then filtered off
  3. washthe filter residue is washed with a small amount of anhydrous tetrahydrofuran
  4. stirringthe mixture is stirred overnight
  5. customThe solvent is then stripped off under reduced pressure on a rotary evaporator
  6. customthe residue is twice recrystallized from isopropanol

출처 및 근거

ORD 기록
ord-4c6d172a25be4ccbbffd592ee14265f9
출처 데이터셋
uspto-grants-1983_06
특허 번호
US04389403

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