HCID 20497520, 화합물 → Ethyl 4-(4-aminobutyl)piperazine-1-carboxylate

HRID 2166923노트

반응식

HRID 2166923 반응식
[C:1]([CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][N:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:8][CH2:7]1)#[N:2]>N.C(O)C.[Rh]>[NH2:2][CH2:1][CH2:3][CH2:4][CH2:5][N:6]1[CH2:7][CH2:8][N:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:10][CH2:11]1

참가 물질

5

반응물 1

HCID 20497520HCID 20497520, 화합물

생성물 1

HCID 20497516Ethyl 4-(4-aminobutyl)piperazine-1-carboxylate수율 32.7%

시약·촉매·용매 3

HCID 23948Rhodium촉매HCID 222Ammonia용매HCID 702Ethanol용매

실험 절차

60 g of ethyl 4-(3-cyanopropyl)-piperazine-1-carboxylate were dissolved in a 10% w/w solution of ammonia in ethanol and 6 g of 5% rhodium on alumina were added thereto. The mixture was cooled to room temperature and filtered. The filtrate was evaporated to dryness under vacuum and the residual oil was distilled under reduced pressure to obtain 20 g of ethyl 4-(4-aminobutyl)-piperazine-1-carboxylate with a boiling point of 126°-130° C. at 0.15 to 0.2 mm Hg.

후처리

  1. additionwere added
  2. filtrationfiltered
  3. customThe filtrate was evaporated to dryness under vacuum
  4. distillationthe residual oil was distilled under reduced pressure

출처 및 근거

ORD 기록
ord-febb1e1e9fd94a0aae15d11aa63c7d03
출처 데이터셋
uspto-grants-1983_06
특허 번호
US04390697

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