Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Citric Acid → Apomorphine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Citric Acid | HCID 311 | — |
| 반응물 | Mannitol | HCID 6251 | — |
| 반응물 | 4H-Dibenzo[de,g]quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride (1:1), (6aR)- | HCID 9410 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Apomorphine | HCID 6005 | — |
반응 단계
Gelatin and mannitol are dispersed in purified water and mixed thoroughly (i.e., using a vacuum mixer) and homogenized. Apomorphine hydrochloride is added and the mixture was again homogenized to ensure complete dissolution of the apomorphine hydrochloride. The pH of the solution is adjusted to about 3.0 (i.e., by addition of a suitable acid, such as citric acid). The solution is then poured onto a sheet and dried in a heated oven.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09044475B2 |
| 출처 데이터셋 | uspto-grants-2015_06 |
| ORD ID | ord-209d9e9339364d4db7de1f3c96ee0a96 |
| 출처 메모 | uspto-grants-2015_06 |