Potassium Carbonate → N-(2-bromo-4-(trifluoromethyl)benzyl)-2,4'-dichloro-2'-methyl-[1,1'-biphenyl]-4-amine

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	2-Bromo-1-(bromomethyl)-4-(trifluoromethyl)benzene	HCID 14949936	—
반응물	2,4'-Dichloro-2'-methyl-[1,1'-biphenyl]-4-amine	HCID 86674205	—
용매	Dimethylformamide	HCID 6228	—
용매	Ethyl Acetate	HCID 8857	—
생성물	N-(2-bromo-4-(trifluoromethyl)benzyl)-2,4'-dichloro-2'-methyl-[1,1'-biphenyl]-4-amine	HCID 86674206	—

반응 조건

온도	80 °C

반응 단계

2-Bromo-1-(bromomethyl)-4-(trifluoromethyl)benzene (2.0 g, 6.3 mmol), 2,4′-dichloro-2′-methyl-[1,1′-biphenyl]-4-amine (1.7 g, 6.9 mmol), and K2CO3 (1.3 g, 9.4 mmol) were diluted with DMF (20 mL) and heated to 80° C. After 3 h the resulting mixture was diluted with EtOAc, washed with water and brine, dried (Na2SO4), and dry packed onto silica gel. Column chromatography yielded the title compound.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09045389B2
출처 데이터셋	uspto-grants-2015_06
ORD ID	ord-19d05245a77e4062a4f4bcf5483b2ec3
출처 메모	uspto-grants-2015_06