Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 1-(2-Bromo-4-chlorophenyl)ethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | 1-(2-Bromo-4-chlorophenyl)ethanone | HCID 4712644 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 1-(2-Bromo-4-chlorophenyl)ethanol | HCID 57445073 | — |
반응 단계
Solid NaBH4 (354 mg, 9.4 mmol) was added to a 0° C., THF (5 mL) and MeOH (15 mL) solution of 1-(2-bromo-4-chlorophenyl)ethanone (1.8 g, 7.8 mmol). After 30 min 2N aqueous HCl was slowly added, and the resulting mixture was extracted with EtOAc. The combined organic extracts were dried (Na2SO4), concentrated, and purified via column chromatography to yield the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09045389B2 |
| 출처 데이터셋 | uspto-grants-2015_06 |
| ORD ID | ord-6e3095ed84a448a09f9240a4b084a0ee |
| 출처 메모 | uspto-grants-2015_06 |