Dimethylformamide → 2,6-Dichloro-4-(trifluoromethyl)benzaldehyde
반응식
[Li]CCCC.[Cl:6][C:7]1[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[C:9]([Cl:17])[CH:8]=1.CN([CH:21]=[O:22])C>C1COCC1>[Cl:6][C:7]1[CH:12]=[C:11]([C:13]([F:14])([F:15])[F:16])[CH:10]=[C:9]([Cl:17])[C:8]=1[CH:21]=[O:22]참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
A 2M n-BuLi solution (5.8 mL, 11.6 mmol) was added to a −78° C. THF solution (60 mL) of 1,3-dichloro-5-(trifluoromethyl)benzene (2.5 g, 11.6 mmol). After 45 min neat DMF (0.39 mL, 5.0 mmol) was added, and the resulting solution was allowed to warm to 0° C. gradually, quenched with NH4Cl solution, and extracted with diethyl ether. The combined extracts were dried (Na2SO4), concentrated, and purified via column chromatography to yield the title compound.
후처리
- customquenched with NH4Cl solution
- extractionextracted with diethyl ether
- dry with materialThe combined extracts were dried (Na2SO4)
- concentrationconcentrated
- custompurified via column chromatography
출처 및 근거
- ORD 기록
- ord-a3100613125448ef867ddb0910b71a8e
- 출처 데이터셋
- uspto-grants-2015_06
- 특허 번호
- US09045389B2
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