Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 1-Acetyl-4-[(benzoxazol-5-yl)imino]-2-methyl-1,2,3,4-tetrahydroquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4(1H)-Quinolinone, 1-acetyl-2,3-dihydro-2-methyl- | HCID 589563 | — |
| 반응물 | 1,3-Benzoxazol-5-amine | HCID 1482188 | — |
| 촉매 | Titanium Tetrachloride | HCID 24193 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-Acetyl-4-[(benzoxazol-5-yl)imino]-2-methyl-1,2,3,4-tetrahydroquinoline | HCID 66625167 | — |
반응 단계
[Step 1] 177 mg of 1-acetyl-4-oxo-2-methyl-1,2,3,4-tetrahydroquinoline and 77 mg of 5-aminobenzoxazole were dissolved in 2 mL of methylene chloride, and 0.32 mL of triethylamine and 0.57 mL of titanium tetrachloride (1.0 M dichloromethane solution) were added to the solution under ice cooling. The mixture was stirred for 16 hours at room temperature. After completion of the reaction, the reaction liquid was filtered through Celite, and was concentrated under reduced pressure. Thus, a crude product of 1-acetyl-4-[(benzoxazol-5-yl)imino]-2-methyl-1,2,3,4-tetrahydroquinoline was obtained as a pale brown solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09045423B2 |
| 출처 데이터셋 | uspto-grants-2015_06 |
| ORD ID | ord-71cc91f2f37c45549dc9943aac84646b |
| 출처 메모 | uspto-grants-2015_06 |