Ammonia → Methyl 3-aminocarbonyl-2-chloro-4-methylsulfonylbenzoate

HRID 2167432노트

반응식

HRID 2167432 반응식
[NH3:1].[Cl:2][C:3]1[C:12]([C:13](Cl)=[O:14])=[C:11]([S:16]([CH3:19])(=[O:18])=[O:17])[CH:10]=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6]>O1CCOCC1>[NH2:1][C:13]([C:12]1[C:3]([Cl:2])=[C:4]([CH:9]=[CH:10][C:11]=1[S:16]([CH3:19])(=[O:18])=[O:17])[C:5]([O:7][CH3:8])=[O:6])=[O:14]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 18517408Methyl 2-chloro-3-chlorocarbonyl-4-methylsulfonylbenzoate

생성물 1

HCID 22114953Methyl 3-aminocarbonyl-2-chloro-4-methylsulfonylbenzoate

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

Ammonia was passed for 2 hours into a solution of 15.0 g (48 mmol) of methyl 2-chloro-3-chlorocarbonyl-4-methylsulfonylbenzoate and 300 ml of dry dioxane. The precipitate formed was filtered off with suction and the filtrate was concentrated. This gave 15.2 g of methyl 3-aminocarbonyl-2-chloro-4-methylsulfonylbenzoate in quantitative yield.

후처리

  1. customThe precipitate formed
  2. filtrationwas filtered off with suction
  3. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-b8165133d8d941fd944499c51ecbe846
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09045465B1

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