Sodium Bicarbonate → 3-Phenyl-2-(1,2,3,4-tetrahydroisoquinolin-7-yl)propanenitrile

HRID 2167442노트

반응식

HRID 2167442 반응식
C(OC([N:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][C:12]([CH:18]([C:26]#[N:27])[CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:13][CH:14]=2)[CH2:9]1)=O)(C)(C)C.C([O-])(O)=O.[Na+]>C(O)=O>[C:20]1([CH2:19][CH:18]([C:12]2[CH:11]=[C:10]3[C:15]([CH2:16][CH2:17][NH:8][CH2:9]3)=[CH:14][CH:13]=2)[C:26]#[N:27])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

참가 물질

4

반응물 2

HCID 516892Sodium BicarbonateHCID 66978151tert-Butyl-7-(1-cyano-2-phenylethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

생성물 1

HCID 667475123-Phenyl-2-(1,2,3,4-tetrahydroisoquinolin-7-yl)propanenitrile수율 85.8%

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

0.171 mmol tert-butyl-7-(1-cyano-2-phenylethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate were dissolved in 1.3 ml formic acid and stirred at room temperature for 1 h. After addition of saturated NaHCO3 solution the mixture was extracted with EtOAc. The combined organic layers were dried over MgSO4 and filtered. Evaporation of the solvent gave 38.5 mg of solid material (86%).

후처리

  1. extractionwas extracted with EtOAc
  2. dry with materialThe combined organic layers were dried over MgSO4
  3. filtrationfiltered
  4. customEvaporation of the solvent

출처 및 근거

ORD 기록
ord-182c55481b8640a6a295e1b419dd7cf6
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09045459B2

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