Triethylamine → (S)-tert-butyl (1-(methylsulfonyl)pyrrolidin-3-yl)carbamate

HRID 2167782노트

반응식

HRID 2167782 반응식
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[NH:6]1[CH2:10][CH2:9][C@H:8]([NH:11][C:12](=[O:18])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15])[CH2:7]1.CCN(CC)CC>C(Cl)Cl>[CH3:1][S:2]([N:6]1[CH2:10][CH2:9][C@H:8]([NH:11][C:12](=[O:18])[O:13][C:14]([CH3:16])([CH3:15])[CH3:17])[CH2:7]1)(=[O:4])=[O:3]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 1514396(3S)-(-)-3-(tert-Butoxycarbonylamino)pyrrolidine

생성물 1

HCID 58959879(S)-tert-butyl (1-(methylsulfonyl)pyrrolidin-3-yl)carbamate수율 58.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

Methane sulfonyl chloride (204 mg, 1.78 mmol) was added to a solution of (S)-tert-butyl pyrrolidin-3-ylcarbamate (300 mg, 1.62 mmol) and Et3N (197 mg, 1.94 mmol) in DCM (6 mL) at 0-5° C.; stirring was continued at 20-35° C. for 2 h. The reaction mixture was diluted with DCM, washed with water, aqueous NaHCO3 solution followed by brine to afford 250 mg of the title compound.

후처리

  1. washwashed with water, aqueous NaHCO3 solution

출처 및 근거

ORD 기록
ord-a4f23f0eac064becb620957e8fa1e220
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09045479B2

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