Ethyl 3-aminocyclohexanecarboxylate → (3-Aminocyclohexyl)methanol

HRID 2167786

반응식

HRID 2167786 반응식
[H-].[H-].[H-].[H-].[Li+].[Al+3].[NH2:7][CH:8]1[CH2:13][CH2:12][CH2:11][CH:10]([C:14](OCC)=[O:15])[CH2:9]1>C1COCC1>[NH2:7][CH:8]1[CH2:13][CH2:12][CH2:11][CH:10]([CH2:14][OH:15])[CH2:9]1

참가 물질

4

반응물 2

HCID 418531Ethyl 3-aminocyclohexanecarboxylateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 55290182(3-Aminocyclohexyl)methanol수율 82.8%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
27.5 °C

실험 절차

LAH (107 mg, 2.8 mmol) was added portionwise to a solution of ethyl 3-aminocyclohexanecarboxylate (320 mg, 1.87 mmol) in THF (5 mL) at 0° C. and continued stirring at 25-30° C. for 15 h. The reaction mixture was quenched with aqueous saturated sodium sulphate solution, filtered the solid precipitate, washed the solid with THF; the filtrate collected was concentrated under reduced pressure to afford 200 mg of the title compound.

후처리

  1. customThe reaction mixture was quenched with aqueous saturated sodium sulphate solution
  2. filtrationfiltered the solid precipitate
  3. washwashed the solid with THF
  4. customthe filtrate collected
  5. concentrationwas concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-d445681ed7bd4fad99140ec9b16f5098
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09045479B2

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