Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 3-(4-Benzyloxy-phenyl)-1,1,1-trifluoro-propan-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Cesium fluoride | HCID 25953 | — |
| 반응물 | (Trifluoromethyl)trimethylsilane | HCID 552549 | — |
| 반응물 | Methyl 2-(4-benzyloxyphenyl)acetate | HCID 2756645 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-(4-Benzyloxy-phenyl)-1,1,1-trifluoro-propan-2-one | HCID 67387207 | — |
반응 단계
A mixture of (4-benzyloxy-phenyl)-acetic acid methyl ester (11.7 mmol, 3.0 g), trimethyl-trifluoromethyl-silane and cesium fluoride in THF may be stirred at room temperature for 2 h. Hydrochloride may be added upon consumption of ester as indicated by TLC. The mixture may be stirred further at room temperature until the intermediate disappears as indicated by TLC to provide 3-(4-benzyloxy-phenyl)-1,1,1-trifluoro-propan-2-one.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09045461B2 |
| 출처 데이터셋 | uspto-grants-2015_06 |
| ORD ID | ord-635bf373a0984232bca548a6e1588bee |
| 출처 메모 | uspto-grants-2015_06 |