(1-Phenylcyclopentyl)acetonitrile → 2-(1-Phenyl-cyclopentyl)-acetamidine HCl salt

HRID 2169157노트

반응식

HRID 2169157 반응식
[C:1]1([C:7]2([CH2:12][C:13]#[N:14])[CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[Cl:16]C1C=CC=CC=1C1C=CC=CC=1CC(N)=[NH:31]>>[ClH:16].[C:1]1([C:7]2([CH2:12][C:13]([NH2:31])=[NH:14])[CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

3

반응물 2

HCID 223258(1-Phenylcyclopentyl)acetonitrileHCID 867257832-(2'-Chloro-biphenyl-2-yl)-acetamidine hydrochloride salt

생성물 1

HCID 867258072-(1-Phenyl-cyclopentyl)-acetamidine HCl salt수율 77.7%

실험 절차

2-(1-Phenyl-cyclopentyl)-acetamidine HCl salt (26-01) (4.2 g, 77.7%) was synthesized from (1-phenyl-cyclopentyl)-acetonitrile (25-01) (4.2 g, 22.703 mmol) as a white gummy solid as a crude product following the procedure as described for 2-(2′-chloro-biphenyl-2-yl)-acetamidine hydrochloride salt (5-02).

출처 및 근거

ORD 기록
ord-571c0a5794a14e1cb8664a6638d6ff3c
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09045486B2

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