2-(2'-Chloro-biphenyl-2-yl)-acetamidine hydrochloride salt → 2-[1-(4-chlorophenyl)-cyclopentyl]-acetamidine HCl salt

반응식

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH2:13][C:14]#[N:15])[CH2:12][CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Cl.ClC1C=CC=CC=1C1C=CC=CC=1CC(N)=[NH:32]>>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([CH2:13][C:14]([NH2:32])=[NH:15])[CH2:12][CH2:11][CH2:10][CH2:9]2)=[CH:6][CH:7]=1

참가 물질

반응물 2

HCID 867257832-(2'-Chloro-biphenyl-2-yl)-acetamidine hydrochloride salt

HCID 86725806HCID 86725806, 화합물

생성물 1

HCID 867258092-[1-(4-chlorophenyl)-cyclopentyl]-acetamidine HCl salt수율 80.21%

실험 절차

2-[1-(4-chlorophenyl)-cyclopentyl]-acetamidine HCl salt (26-02) (6 g, 80.21%) was synthesized from [1-(4-chlorophenyl)-cyclopentyl]-acetonitrile (25-02) (6 g, 27.39 mmol) as a white gummy solid as a crude product following the procedure as described for 2-(2′-chloro-biphenyl-2-yl)-acetamidine hydrochloride salt (5-02).

출처 및 근거

ORD 기록: ord-a75133f08beb425bb7194f80599f2554
출처 데이터셋: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09045486B2

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