Water → 3-(Methylsulfonyloxy)phenylboronic acid

HRID 216934

반응식

HRID 216934 반응식
[OH:1][C:2]1[CH:3]=[C:4]([B:8]([OH:10])[OH:9])[CH:5]=[CH:6][CH:7]=1.[CH3:11][S:12](Cl)(=[O:14])=[O:13].O.C(OCC)(=O)C>N1C=CC=CC=1>[CH3:11][S:12]([O:1][C:2]1[CH:3]=[C:4]([B:8]([OH:10])[OH:9])[CH:5]=[CH:6][CH:7]=1)(=[O:14])=[O:13]

참가 물질

6

반응물 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 31297Methanesulfonyl chlorideHCID 2734359(3-hydroxyphenyl)boronic Acid

생성물 1

HCID 595685463-(Methylsulfonyloxy)phenylboronic acid

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To 3-hydroxyphenylboronic acid (10 g) stirred in pyridine (40 mL) at 0° C. was added methanesulfonyl chloride (8 mL). The reaction mixture was stirred for 1 h at room temperature and then water and ethyl acetate was added. The organic layer was separated and the aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with dilute HCl washed with brine, dried over magnesium sulfate. The resulting solid was recrystallizated from petroleum ether and ethyl acetate to give the sub-titled compound (12 g).

후처리

  1. customThe organic layer was separated
  2. extractionthe aqueous layer was extracted with ethyl acetate
  3. washThe combined organic layers were washed with dilute HCl
  4. washwashed with brine
  5. dry with materialdried over magnesium sulfate

출처 및 근거

ORD 기록
ord-aad4af688c5041da92cf3c20de86cadc
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08193239B2

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